Cite this article as: Niraula S. The mediating role of marital boredom in the relationship between emotional divorce with self-differentiation and Conversation with AI (Chat GPT) about counseling a patient with Sickle Cell Disease. Soc Determinants Health. 2024, 10(1): 1-6. DOI: http: //dx. doi. org/10. 22037/sdh. v10i1. 46268 Dear Editor, hat GPT is an AI based chat bot created by San Francisco based AI Company named open AI in November 2022. GPT is an abbreviation for Generative Pre-trained Transformer. It is built to understand and generate human-like text based on the input it receives and involves vast amounts of data from the internet, encompassing a wide array of topics, languages, and styles of communication. (1) Chat GPT is gaining immense popularity around the world because of its wide range of knowledge and capabilities. These AI model generated texts are often indistinguishable from human written text. It can hold conversations on various topics whether they are creative, educational, and technical or some casual talks. (2) This chat bot has multilingual support and can help assist in writing essays, generating creative content, summarizing articles, providing study tips, answering trivia questions, and more.